Sodium Hydroxide → HCID 18331271, compound

Participants

Reaction Steps

To a mixed solution of 269 mg (0.78 mmol) of the compound obtained in Example 2 in 3 ml of tetrahydrofuran and 3 ml of ethanol, 857 μl (0.857 mmol) of 1N sodium hydroxide solution was added at room temperature and the solution was stirred at that temperature for 1.5 hours. Next, this was diluted with water (20 ml) and, after washing with ether (10 ml), 1N hydrochloric acid (0.87 ml) was added to an aqueous layer. After extracting with methylene chloride (40 ml), the extract was dried over anhydrous sodium sulfate, then the solvent was distilled off under vacuum. Thus, 237 mg (96%) of the above-identified compound was obtained as a slightly yellow crystal.

Provenance & Evidence