2-(2-Formyl-6-methoxyphenoxy)acetaldehyde → 7-Methoxy-1-benzofuran-2-carbaldehyde

Participants

Reaction Steps

2-(2-Formyl-6-methoxyphenoxy)acetaldehyde, dimethyl acetal (31 g) was heated to reflux in glacial acetic acid (120 ml) overnight. The mixture was then cooled and the solvent removed in vacuo to give a red oil. Purification by Kugelrohr distillation gave the title compound (17 g) as a pale yellow oil which solidified on standing.

Provenance & Evidence