4-Chloro-1-methyl-1H-pyrazol-5-amine → HCID 9924517, compound

HRID 2270126Notes

Reaction equation

HRID 2270126 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:15]([OH:17])=O)=[C:7]2[C:11]=1[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8]2.[Cl:18][C:19]1[CH:23]=[N:22][N:21]([CH3:24])[C:20]=1[NH2:25]>>[Cl:18][C:19]1[CH:23]=[N:22][N:21]([CH3:24])[C:20]=1[NH:25][C:15]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:11]2[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8][C:7]=12)=[O:17]

Participants

3

Reactant 2

HCID 137826424-Chloro-1-methyl-1H-pyrazol-5-amineHCID 18423641HCID 18423641, compound

Product 1

HCID 9924517HCID 9924517, compound

Procedure

Starting from 7-methoxy-2-methoxymethylbenzofuran-4-carboxylic acid (0.14 g) and 4-chloro-2-methyl-2H-pyrazol-3-ylamine (78 mg). Purification by column chromatography on silica eluting with 50%-75% ethyl acetate in hexane afforded the title compound as an off white solid (34 mg).

Workup

  1. customPurification by column chromatography on silica eluting with 50%-75% ethyl acetate in hexane

Sources & evidence

ORD record
ord-7e2ee8026f834df3b50f64dd4ef9e4d7
Source dataset
uspto-grants-2001_12
Patent number
US06331556B2

Reaction notes

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