4-(Trifluoromethyl)benzylamine → 3,5-Dimethylisoxazole-4-carboxamide

HRID 2270136Notes

Reaction equation

HRID 2270136 reaction equation
FC(F)(F)[N:3](C1C=CC=CC=1)[C:4]([C:6]1[C:7]([CH3:12])=[N:8][O:9][C:10]=1[CH3:11])=[O:5].FC(F)(F)C1C=CC(CN)=CC=1>>[CH3:12][C:7]1[C:6]([C:4]([NH2:3])=[O:5])=[C:10]([CH3:11])[O:9][N:8]=1

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 54309734HCID 54309734, compound

Product 1

HCID 7364783,5-Dimethylisoxazole-4-carboxamide

Procedure

P22 was made using the same conditions as described for N-trifluoromethylphenyl 3,5-dimethylisoxazole-4-carboxamide (A13), but starting with 4-trifluoromethylbenzylamine.

Sources & evidence

ORD record
ord-8f0e5aff448b4be5881db33eda3ebaf7
Source dataset
uspto-grants-2001_12
Patent number
US06331555B1

Reaction notes

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