HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2270144Generated: October 31, 2026
Potassium Carbonate → HCID 18331486, compound
https://huagongshe.com/reaction/2270144
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (4-Chlorophenyl)acetic acid | HCID 15880 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2,4'-Dihydroxy-4-methoxybenzophenone | HCID 282356 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18331486 | HCID 18331486 | — |
Reaction Steps
A suspension of 2-hydroxy-4-methoxyphenyl 4-hydroxyphenyl ketone (2.6 grams, 10.65 mmol), 4-chlorophenylacetic acid (4.0 g, 23.43 mmol), K2CO3 (4.4 g, 31.95 mmol), carbonyldiimidazole (3.8 g, 23.43 mmol), and 4-dimethylaminopyridine (0.1 g,) in 20 mL of DMF was warmed at 90° C. for 5 hours. The reaction mixture was poured into 150 mL of H2O and stirred for 30 minutes. The precipitated product was collected by filtration and the purified desired product was isolated following flash chromatography (2.1 g, 52%, LC/MS=379 (M+H+)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06331562B1 |
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| Source dataset | uspto-grants-2001_12 |
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| ORD ID | ord-32108088900f494fa43cfbd608de22f8 |
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| Source note | uspto-grants-2001_12 |
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