Hydrochloric Acid → HCID 57754654, compound

Participants

Reaction Conditions

Reaction Steps

A 4M solution of hydrochloric acid in dioxane (4 mL) was added to 381 mg (0.991 mmol) of 1-(4-Methoxy-benzyl)-3-(5-methyl-pyridine-2-carbonyl)-1H-quinolin-4-one and was heated in a pressure tube at 120° C. for 18 h. The reaction was concentrated and saturated sodium bicarbonate was added and the aqueous phase was extracted with dichloromethane (3×20 mL). The crude product was purified by flash column chromatography using a gradient of 70:30 ethyl acetate/methanol to afford 68.4 mg of 3-(5-Methyl-pyridine-2-carbonyl)-1H-quinolin-4-one.

Provenance & Evidence