HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → HCID 22632998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 22632919 | HCID 22632919 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 22632998 | HCID 22632998 | 77.8% |
Reaction Steps
Using the General Method 5, the reaction of N-benzyloxy-2,6-dichloro-5-fluoro-3-pyridinecarboxamide (Example M-2, 2.00 g, 6.34 mmol) and 60% NaH in oil (380 mg, 9.52 mmol) with ethyl isocyanate (2.0 mL, 25.36 mmol) in DMA afforded 1.725 g of the title compound as a solid, mp 156-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331538B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-58d0c94b00654b139fc2a6a733d64470 |
| Source note | uspto-grants-2001_12 |