Pyrrolidine → HCID 22633028, compound

Participants

Reaction Steps

To a solution of 3-benzyloxy-7-chloro-1-ethyl-6-fluoro-1H-pyrido[2,3-d]-pyrimidine-2,4-dione (Example N-2, 146 mg, 0.42 mmol) in dichloromethane (3 mL) was added pyrrolidine (0.070 mL, 0.84 mmol) and the mixture was stirred at room temperature for 10 minutes. The reaction was diluted with dichloromethane (10 mL). The organic phase was washed with saturated aqueous sodium bicarbonate, dried on MgSO4, and concentrated. Washing the solid residue with hexane afforded 120 mg of the title compound as a solid, mp 189-190° C.

Provenance & Evidence