HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Amino-N-benzyloxy-3,4,5,6-tetrafluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Benzyloxyamine hydrochloride | HCID 102312 | — |
| Reactant | 2-Amino-3,4,5,6-tetrafluorobenzoic acid | HCID 688185 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Amino-N-benzyloxy-3,4,5,6-tetrafluoro-benzamide | HCID 22632879 | 106.1% |
Reaction Steps
Following the procedure for Example A, 2-amino-3,4,5,6-tetrafluorobenzoic acid (3.0 g, 14.4 mmol) was reacted with carbonyldiimidazole (2.8 g, 17.2 mmol), O-benzylhydroxylamine hydrochloride (3.44 g, 21.5 mmol), and triethylamine (3.0 mL, 21.5 mmol) in THF (50 mL) to provide 4.8 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331538B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-1e111692dc1f4504957b08aba6a257cf |
| Source note | uspto-grants-2001_12 |