HCID 22632866, compound → HCID 22632959, compound

HRID 2270278Notes

Reaction equation

HRID 2270278 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:26])=[C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)[CH:17]=3)[C:12](=[O:27])[N:11]([O:28]CC3C=CC=CC=3)[C:10]2=[O:36])[CH:5]=[CH:6][C:7]=1[F:8]>[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:26])=[C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)[CH:17]=3)[C:12](=[O:27])[N:11]([OH:28])[C:10]2=[O:36])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 1

HCID 22632866HCID 22632866, compound

Product 1

HCID 22632959HCID 22632959, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A. the reaction of 10% Pd/C (0.06 g) with 1-(3-chloro-4-fluorophenyl)-6-fluoro-3-benzyloxy-7-(4-methylpiperazin-1-yl)-1H-quinazoline-2,4-dione (Example R-1, 0.12 g, 0.23 mmol) afforded 0.085 g of the title compound as a solid, mp 197-199° C.

Sources & evidence

ORD record
ord-981da6fc1f66461f9c79487ec39afdf3
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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