Tetrahydrofuran → HCID 53627949, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60 from 327 mg (0.81 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 4 mL THF and 527 mg (2.03 mmol) of 2-iodo-5,6,7,8-tetrahydro-quinoline in 2 mL THF with 1.01 mL 2M isopropylmagnesium chloride. Yield: 28 mg of a white powder. LC-MSD, m/z for C25H20BrN3O2 [M+H]+=474.0, 476.0; HPLC retention time: 2.5 min.

Provenance & Evidence