HCID 22633004, compound → HCID 22632909, compound

HRID 2270281Notes

Reaction equation

HRID 2270281 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:32])=[C:16]([N:19]4[CH2:23][CH2:22][CH:21]([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:20]4)[CH:17]=3)[C:12](=[O:33])[N:11]([O:34]CC3C=CC=CC=3)[C:10]2=[O:42])[CH:6]=[CH:7][CH:8]=1>[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:32])=[C:16]([N:19]4[CH2:23][CH2:22][CH:21]([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:29])[CH3:30])=[O:26])[CH2:20]4)[CH:17]=3)[C:12](=[O:33])[N:11]([OH:34])[C:10]2=[O:42])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 22633004HCID 22633004, compound

Product 1

HCID 22632909HCID 22632909, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.05 g) with 1-(3-methoxyphenyl)-6-fluoro-3-benzyloxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione (Example V-1, 0.15 g, 0.26 mmol) afforded 0.12 g of 1-(3-methoxyphenyl)-6-fluoro-3-hydroxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione as a solid.

Sources & evidence

ORD record
ord-0bca2afdaa594acb9fc7ba67d10d1348
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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