HCID 22632992, compound → HCID 22633021, compound

HRID 2270284Notes

Reaction equation

HRID 2270284 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:24])[N:10]([O:25]CC3C=CC=CC=3)[C:9]2=[O:33])[CH:5]=[CH:6][CH:7]=1>[Pd]>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:19][CH2:20][CH2:21][CH2:22]4)[CH:16]=3)[C:11](=[O:24])[N:10]([OH:25])[C:9]2=[O:33])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 22632992HCID 22632992, compound

Product 1

HCID 22633021HCID 22633021, compoundYield 113.8%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.03 g) with 1-(3-fluorophenyl)-6-fluoro-3-benzyloxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example Y-1, 0.1 g, 0.22 mmol) provided 0.09 g of the title compound as a solid, mp 239-241° C.

Sources & evidence

ORD record
ord-23a6efa5653c4453a9cab04186216fd9
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

Loading…