Acetyl chloride → HCID 69959246, compound

HRID 2270287Notes

Reaction equation

HRID 2270287 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:27])[C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([CH:28]2[CH2:30][CH2:29]2)[C:10]1=[O:31])C1C=CC=CC=1.C([Cl:35])(=O)C>CO.[Pd]>[ClH:35].[CH:28]1([N:11]2[C:12]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]4)[C:17]([F:27])=[CH:16][C:13]=3[C:14](=[O:15])[N:9]([OH:8])[C:10]2=[O:31])[CH2:29][CH2:30]1

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 22632892HCID 22632892, compound

Product 1

HCID 69959246HCID 69959246, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Following the procedure of Example 32, the reaction of 3-benzyloxy-1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example L-2, 65 mg, 0.157 mmol), 10% Pd/C (30 mg) in MeOH (3 mL) under a hydrogen atmosphere, followed by adding a few drop of acetyl chloride into the reaction mixture provided 45 mg of the title compound as powder, mp >300° C. (decomp.).

Sources & evidence

ORD record
ord-66beefc796c740e28fbf3ad089ce84f7
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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