2-Iodo-4,5-dimethylpyridine → HCID 57754629, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60 from 86 mg (0.21 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 125 mg (0.54 mmol) of 2-iodo-4,5-dimethyl-pyridine in 1 mL THF with 0.28 mL 2M isopropylmagnesium chloride using. Yield: 21 mg of a white powder. LC-MSD, m/z for C23H18BrN3O2 [M+H]+=448.0, 450.0; HPLC retention time: 2.2 min.

Provenance & Evidence