HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → HCID 57754568, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide | HCID 57754532 | — |
| Solvent | Bromide ion | HCID 259 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57754568 | HCID 57754568 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 6 of Example 60 from 120 mg (0.30 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 1.3 mL 0.5M 3-N,N-dimethylanilinemagnesium bromide. Yield: 97 mg of a yellow solid. LC-MSD, m/z for C24H20BrN3O2 [M+H]+=462.0, 464.0; HPLC retention time: 2.2 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-c71d38da5a5b4e5aa4be37aec1b59d2c |
| Source note | uspto-grants-2009_07 |