HCID 11003329, compound → HCID 11089356, compound

HRID 2270329Notes

Reaction equation

HRID 2270329 reaction equation
C([O:3][C:4](=[O:26])[C:5]([S:14]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:16])=[O:15])([CH3:13])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>CO.[OH-].[Na+]>[CH3:25][O:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][S:14]([C:5]([CH3:13])([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([OH:26])=[O:3])(=[O:15])=[O:16])=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 11003329HCID 11003329, compound

Product 1

HCID 11089356HCID 11089356, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-(4-Methoxy-phenylmethanesulfonyl)-2-methyl-3-phenyl-propionic acid was prepared starting from 2-(4-Methoxy-phenylmethanesulfonyl)-2-methyl-3-phenyl-propionic acid ethyl ester (3.5 g, 9.0 mmol) dissolved in methanol (50 ml) and 10 N NaOH (30 ml). The resulting reaction mixture was worked up as outlined in Example 9. Yield 930 mg, 31%. Colorless solid, mp: 106-108 C;. MS: 347 (M−H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-5607c17c536b4d779619837a6ea0d4f6
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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