4-(2-Piperidin-1-yl-ethoxy)benzyl chloride → 2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH:5]([S:7]([C:10]1[CH:14]=[CH:13][O:12][C:11]=1[CH3:15])(=[O:9])=[O:8])[CH3:6])[CH3:2].Cl[CH2:18][C:19]1[CH:33]=[CH:32][C:22]([O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4](=[O:16])[C:5]([CH3:6])([S:7]([C:10]1[CH:14]=[CH:13][O:12][C:11]=1[CH3:15])(=[O:8])=[O:9])[CH2:18][C:19]1[CH:33]=[CH:32][C:22]([O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:21][CH:20]=1)[CH3:2]Participants
3
Procedure
2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-(2-methyl-furan-3-sulfonyl)-propionic acid ethyl ester (2.4 g, 9.8 mmol) and 1-[2-(4-chloromethylphenoxy)-ethyl]-piperidine (2.96 g, 10.7 mmol); Yield 2.4 g (92%); amber oil; MS 464.2 (M+H)+.
Sources & evidence
- ORD record
- ord-a193e208a8994ca1867d0e72b1311b86
- Source dataset
- uspto-grants-2001_12
- Patent number
- US06331563B1
Reaction notes
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