HCID 54016540, compound → HCID 18416718, compound

HRID 2270340Notes

Reaction equation

HRID 2270340 reaction equation
C([O:3][C:4](=[O:26])[C:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:17])=[O:16])([CH3:14])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)C>CO.[OH-].[Na+]>[Br:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C:5]([S:15]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=2)(=[O:17])=[O:16])([CH3:14])[C:4]([OH:26])=[O:3])=[CH:12][CH:11]=1

Participants

4

Reactant 1

HCID 54016540HCID 54016540, compound

Product 1

HCID 18416718HCID 18416718, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

3-(4-Bromo-phenyl)-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionic acid was prepared starting from 3-(4-bromo-phenyl)-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionic acid ethyl ester (4.0 g, 9.0 mmol) dissolved in methanol (50 ml) and 10 N NaOH (30 ml). The resulting reaction mixture was worked up as outlined in Example 9. Yield 3.0 g, 78%. Low melting solid. MS: 413 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-9a8d2b5766654f8a8b1aec1e4c5cc889
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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