HCID 54465219, compound → 1-[(4-Methoxyphenyl)sulfonyl]cyclopentanecarboxylic acid

HRID 2270342Notes

Reaction equation

HRID 2270342 reaction equation
C([O:3][C:4]([C:6]1([S:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([S:11]([C:6]2([C:4]([OH:5])=[O:3])[CH2:10][CH2:9][CH2:8][CH2:7]2)(=[O:13])=[O:12])=[CH:15][CH:16]=1

Participants

4

Reactant 1

HCID 54465219HCID 54465219, compound

Product 1

HCID 151305191-[(4-Methoxyphenyl)sulfonyl]cyclopentanecarboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-(4-Methoxy-benzenesulfonyl)-cyclopentanecarboxylic acid was prepared starting from 1-(4-methoxy-benzenesulfonyl)-cyclopentanecarboxylic acid ethyl ester (2.2 g, 7.0 mmol) dissolved in methanol (50 ml) and 10 N NaOH (30 ml). The resulting reaction mixture was worked up as outlined in Example 9. Yield 1.66 g 83%. Colorless solid; mp 112-115° C.; MS: 285 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-250186f0bbef4213ba6f9c158c7fb9b5
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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