HCID 53690752, compound → HCID 18416828, compound

HRID 2270345Notes

Reaction equation

HRID 2270345 reaction equation
C([O:3][C:4](=[O:35])[C:5]([S:24]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)(=[O:26])=[O:25])([CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C>CO.[OH-].[Na+]>[CH3:34][O:33][C:30]1[CH:29]=[CH:28][C:27]([S:24]([C:5]([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)([CH2:15][CH2:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:4]([OH:35])=[O:3])(=[O:25])=[O:26])=[CH:32][CH:31]=1

Participants

4

Reactant 1

HCID 53690752HCID 53690752, compound

Product 1

HCID 18416828HCID 18416828, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-(4-Methoxy-benzenesulfonyl)-5-phenyl-2-(3-phenyl-propyl)-pentanoic acid was prepared starting from 2-(4-methoxy-benzenesulfonyl)-5-phenyl-2-(3-phenyl-propyl)-pentanoic acid ethyl ester (2.0 g, 4 mmol) dissolved in methanol (50 ml) and 10 N NaOH (30 ml). The resulting reaction mixture was worked up as outlined in Example 9. Yield 1.18 g, 63%. Waxy solid; MS: 449.2 (M+H−H2O)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-b1d78956d88f4c15a147e4ff7edb46d9
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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