1-Bromo-2-butyne → HCID 53788027, compound

HRID 2270351Notes

Reaction equation

HRID 2270351 reaction equation
[C:1]([O:5][C:6](=[O:19])[CH2:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)(=[O:10])=[O:9])([CH3:4])([CH3:3])[CH3:2].Br[CH2:21][C:22]#[C:23][CH3:24]>>[C:1]([O:5][C:6](=[O:19])[C:7]([S:8]([C:11]1[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=1)(=[O:9])=[O:10])([CH2:16][C:11]#[C:12][CH3:13])[CH2:21][C:22]#[C:23][CH3:24])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 54318102HCID 54318102, compound

Product 1

HCID 53788027HCID 53788027, compoundYield 90%

Procedure

2-(4-Methoxy-benzenesulfonyl)-2-but-2-ynyl-hex-4-ynoic acid tert-butyl ester was prepared according to the procedure as outlined in Example 9. Starting from 2-(4-methoxy-benzenesulfonyl)-acetic acid tert-butyl ester (2.86 g, 10 mmol) and 1-bromo-2-butyne (2.68 g, 20 mmol), 3.50 g of the product was isolated. Yield 90%; white solid; mp 85-87° C.; MS: 391.0 (M+H)+.

Sources & evidence

ORD record
ord-b8abf3e7e4004697a3dc147847acd68e
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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