1-Bromo-2-butyne → HCID 54416831, compound

HRID 2270357Notes

Reaction equation

HRID 2270357 reaction equation
[C:1]([O:5][C:6](=[O:18])[CH2:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])([CH3:4])([CH3:3])[CH3:2].Br[CH2:20][C:21]#[C:22][CH3:23]>>[C:1]([O:5][C:6](=[O:18])[C:7]([S:8]([C:11]1[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=1)(=[O:10])=[O:9])([CH2:16][C:11]#[C:12][CH3:13])[CH2:20][C:21]#[C:22][CH3:23])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 53983978HCID 53983978, compound

Product 1

HCID 54416831HCID 54416831, compoundYield 77%

Procedure

2-(4-Fluoro-benzenesulfonyl)-2-but-2-ynyl-hex-4-ynoic acid tert-butyl ester was prepared according to the procedure as outlined in Example 9. Starting from 2-(4-fluoro-benzenesulfonyl)-acetic acid tert-butyl ester (4.87 g, 20 mmol) and 1-bromo-2-butyne (5.36 g, 40 mmol), 6.0 g of the product was isolated. Yield 77%; white solid; mp 85° C.; MS: 379.1 (M+H)+.

Sources & evidence

ORD record
ord-9754e4f133fb47db8f8d2d082fe4052c
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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