HCID 10981489, compound → HCID 11002348, compound

HRID 2270377Notes

Reaction equation

HRID 2270377 reaction equation
C([O:3][C:4]([C:6]1([S:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:11][CH2:10][N:9]([CH:12]([CH3:14])[CH3:13])[CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH:12]([N:9]1[CH2:10][CH2:11][C:6]([S:15]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=2)(=[O:17])=[O:16])([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1)([CH3:14])[CH3:13]

Participants

4

Reactant 1

HCID 10981489HCID 10981489, compound

Product 1

HCID 11002348HCID 11002348, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-Isopropyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-isopropyl4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (5.6 g, 15.2 mmol) dissolved in methanol (75 ml) and 10 N NaOH (25 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 2.18 g (42%); white powder; mp 204 ° C.; MS: 341.9 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-f3fc23a258fe4ec6a81dd24baa97f009
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

Loading…