Sodium Hydroxide → HCID 11026180, compound

Participants

Reaction Steps

4-(4Methoxy-benzenesulfonyl)1-(4-methoxy-benzyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4Methoxy-benzenesulfonyl)-1-(4-methoxy-benzyl)piperidine-4carboxylic acid ethyl ester (4.2 g, 10 mmol) dissolve in methanol (30 mL), 10 N sodium hydroxide (10 mL), tetrahydrohydrofuran (20 mL). The resulting reaction mixture was worked up as outlined in example 83. Yield 3.0 g (71%). white solid mp 190° C., MS: 420.4 (M+H)+.

Provenance & Evidence