HCID 10915970, compound → HCID 18331511, compound

HRID 2270397Notes

Reaction equation

HRID 2270397 reaction equation
C([O:3][C:4]([C:6]1([S:13]([C:16]2[CH:21]=[CH:20][C:19](OCCCC)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH3:12][N:9]1[CH2:10][CH2:11][C:6]([S:13]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=2[O:3][CH2:4][CH2:6][CH2:7][CH3:8])(=[O:15])=[O:14])([C:4]([OH:3])=[O:5])[CH2:7][CH2:8]1

Participants

4

Reactant 1

HCID 10915970HCID 10915970, compound

Product 1

HCID 18331511HCID 18331511, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-Methyl-4-(butoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-methyl-4-(4butoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (7.6 g, 20 mmol) dissolved in methanol (300 ml) and 10 N NaOH (35 ml). The resulting reaction mixture was worked up outlined in example 83. Yield 6.0 (84%); white solid; mp 195° C.; MS:356.4 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-8c79f40b850a4f2bbc3303e3706d38fa
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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