HCID 10950201, compound → HCID 11025967, compound

HRID 2270400Notes

Reaction equation

HRID 2270400 reaction equation
C([O:3][C:4]([C:6]1([S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C>C1COCC1.CO.[OH-].[Na+]>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([O:22][C:19]2[CH:18]=[CH:17][C:16]([S:13]([C:6]3([C:4]([OH:5])=[O:3])[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]3)(=[O:14])=[O:15])=[CH:21][CH:20]=2)=[CH:28][CH:27]=1

Participants

4

Reactant 1

HCID 10950201HCID 10950201, compound

Product 1

HCID 11025967HCID 11025967, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

4-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-methyl-piperidine-4-carboxylic acid was prepared starting from 4[4-(4-chloro-phenoxy)-benzenesulfonyl]-1-methyl-piperidine-4-carboxylic acid ethyl ester (4.3 g, 10 mmol) dissolved in THF:methanol (3:1 150 ml) and 10 N NaOH (100 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 3.5g (86%); white solid; mp 185° C.; MS:410(M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-808d3091a99f4e8a9ef18350d153df48
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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