N-Benzylnormechlorethamine → HCID 11827040, compound

HRID 2270409Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:22])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:11][CH:10]=1)(=[O:8])=[O:7])[CH3:2].Cl[CH2:24][CH2:25][N:26]([CH2:34][CH2:35]Cl)[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:1]([O:3][C:4]([C:5]1([S:6]([C:9]2[CH:10]=[CH:11][C:12]([O:15][CH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:13][CH:14]=2)(=[O:7])=[O:8])[CH2:24][CH2:25][N:26]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:34][CH2:35]1)=[O:22])[CH3:2]

Participants

Reactant 2

HCID 5928N-Benzylnormechlorethamine

HCID 11067434HCID 11067434, compound

Product 1

HCID 11827040HCID 11827040, compound

Procedure

1-Benzyl-4-[4-(2-ethyl-butoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method outlined in example 83 starting from [4-(2-ethyl-butoxy)-phenylsulfonyl]-acetic acid ethyl ester (6.4 g, 20 mmol) and bis-(2-chloro-ethyl)-benzyl amine (6.44 g, 24 mmol). Yield 8 g (82%); yellow oil; MS: 488 (M+H)+

Sources & evidence

ORD record: ord-1525fb686a534215bd34cab4e475048b
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331563B1

Reaction notes

Loading…