HCID 11812362, compound → HCID 10994203, compound

HRID 2270411Notes

Reaction equation

HRID 2270411 reaction equation
C([O:3][C:4]([C:6]1([S:21]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.[CH2:32]1[CH2:36]OC[CH2:33]1.CO>[OH-].[Na+]>[CH2:31]([O:30][C:27]1[CH:26]=[CH:25][C:24]([S:21]([C:6]2([C:4]([OH:3])=[O:5])[CH2:11][CH2:10][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH2:8][CH2:7]2)(=[O:22])=[O:23])=[CH:29][CH:28]=1)[CH2:33][CH2:32][CH3:36]

Participants

4

Reactant 2

HCID 11812362HCID 11812362, compoundHCID 21899815MeOH tetrahydrofuran

Product 1

HCID 10994203HCID 10994203, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-(4-Butoxy-benzenesulfonyl)-1-(3-methoxy-benzyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4-methoxy-benzenesulfonyl)-1-(3-methoxy-benzyl)-piperidine-4-carboxylic acid ethyl ester (2.61 g, 5.34 mmol) dissolved in THF:methanol (3:1 150 ml) and 10 N NaOH (15 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 1 g (41%); brown solid; mp 175° C.; MS: 462.0 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-ba740e4a70f14b8bb4b9b2d82bd0c303
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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