3,4-Dichloro-N,N-bis(2-chloroethyl)benzenemethanamine → HCID 11005920, compound

HRID 2270414Notes

Reaction equation

HRID 2270414 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:11][CH:10]=1)(=[O:8])=[O:7])[CH3:2].[Cl:21][C:22]1[CH:23]=[C:24]([CH:33]=[CH:34][C:35]=1[Cl:36])[CH2:25][N:26]([CH2:30][CH2:31]Cl)[CH2:27][CH2:28]Cl>>[CH2:1]([O:3][C:4]([C:5]1([S:6]([C:9]2[CH:10]=[CH:11][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:13][CH:14]=2)(=[O:7])=[O:8])[CH2:28][CH2:27][N:26]([CH2:25][C:24]2[CH:33]=[CH:34][C:35]([Cl:36])=[C:22]([Cl:21])[CH:23]=2)[CH2:30][CH2:31]1)=[O:20])[CH3:2]

Participants

3

Reactant 2

HCID 4139643,4-Dichloro-N,N-bis(2-chloroethyl)benzenemethanamineHCID 11808743HCID 11808743, compound

Product 1

HCID 11005920HCID 11005920, compound

Procedure

4-(4-Butoxy-benzenesulfonyl)-1-(3,4-dichloro-benzyl)-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method outlined in example 83. Starting from (4-butoxy-benzenesulfonyl)acetic acid ethyl ester (13.2 g 44 mmol) (3,4-dichloro-benzyl)-bis-(2-chloro-ethyl)-amine (14.3 g, mmol). Yield 14.1 g (60%), white solid, MP 86° C.; MS: 527.9 (.M+H)+

Sources & evidence

ORD record
ord-60eb40c1ab7b40bfb8b6baf1bbb9c979
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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