HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 18416806, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 53876130 | HCID 53876130 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18416806 | HCID 18416806 | — |
Reaction Steps
[4-(4-Chloro-benzyloxy)-benzenesulfonyl-1-methylpiperidine-4-carboxylic acid was prepared starting from [4-(4-Chloro-benzyloxy)-benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid ethyl ester (10.7 g, 24 mmol) dissolved in THF:Methanol (75:75 ml) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 4.9 g (50%); off white solid; MS: 426.2 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331563B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-79d56948f23a4a958ad9f58a8cb3a916 |
| Source note | uspto-grants-2001_12 |