Methanol → HCID 18416779, compound

Participants

Reaction Steps

4(4Butoxy-benzenesulfonyl)-1-(4cyanobenzyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4-Butoxy-benzenesulfonyl)-1-(4-cyano-benzyl)-piperidine-4-carboxylic ethyl ester (10.0 g, 124 mmol) dissolved in THF:Methanol (75:50 ml) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 0.7 g (11%); off white solid; MS: 456.0 (M+H)+

Provenance & Evidence