5-Ethyl-2-methylpyridine → 3-(4-cyano-5-ethylsulfonylamino-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Conditions

Reaction Steps

1.2 g (2.5 mmol) of 3-(4-bromo-5-ethylsulfonylamino-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)pyrimidinedione, 0.15 g of sodium cyanide and 0.04 g of zinc chloride were added to 5 ml of 5-ethyl-2-picoline and the mixture was stirred at 120° C. under an argon atmosphere for 1 hour. Next, 0.6 g of tetrakis(triphenylphosphine)palladium was added to the mixture, which was then heated with stirring for 10 hours. After the reaction was completed, the title compound was obtained with a yield of 90% as determined by the internal standard method in liquid chromatography.

Provenance & Evidence