HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2270441Generated: October 30, 2026
Hydroxyamine hydrochloride → 5-[4-[4-(4-Fluorophenyl)piperazin-1-yl]butyl]4-hydroxyimino-2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazine 1,1-dioxide
https://huagongshe.com/reaction/2270441
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 5-[4-[4-(4-Fluorophenyl)piperazin-1-yl]butyl]-2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazin-4-one 1,1-dioxide | HCID 9910796 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-[4-[4-(4-Fluorophenyl)piperazin-1-yl]butyl]4-hydroxyimino-2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazine 1,1-dioxide | HCID 72611999 | 88.4% |
Reaction Steps
A suspension of 174 mg (0.4 mmol) of Compound 23 and 111 mg (1.6 mmol) of hydroxylamine hydrochloride in 10 ml of pyridine was stirred for 24 hours over an oil bath of 80° C. Post-treatment and purification were conducted in a similar manner as in Example 21, whereby 159 mg of the title compound were obtained (yield: 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06331623B1 |
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| Source dataset | uspto-grants-2001_12 |
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| ORD ID | ord-e419b59dc9f14c3a8cefb7fb03bba9d7 |
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| Source note | uspto-grants-2001_12 |
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