5-Iodo-2-(trifluoromethyl)pyridine → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(6-trifluoromethyl-pyridine-3-carbonyl)-1H-quinolin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60 from 120 mg (0.30 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 179 mg (0.66 mmol) of 5-iodo-2-trifluoromethyl-pyridine in 1 mL THF with 0.34 mL 2M isopropylmagnesium chloride. Yield: 76 mg of a white powder. LC-MSD, m/z for C22H13BrF3N3O2 [M+H]+=488.0, 490.0; HPLC retention time: 2.5 min.

Provenance & Evidence