Triethylamine → HCID 11791389, compound

Participants

Reaction Steps

A solution formed by dissolving 5.0 g of 2,2,4,4-tetrachloro-3-isobutoxycyclobutanone (compound (I)) and 3.6 g of triethylamine in 50 ml of tert-butyl methyl ether was refluxed for four hours. After cooling to room temperature, the solution was washed using 50 ml of 1 mol/L hydrochloric acid, and the organic layer was concentrated. The concentrated residues were separated by means of silica gel column chromatography (the composition of the developing solvent: n-hexane / ethyl acetate=100/1), to yield 3.3 g of the compound (II), 2,4,4-trichloro-3-isobutoxy-2-cyclobutene-1-one (yield=77%).

Provenance & Evidence