Leucine, N-carboxy-, N-benzyl ester, L- → (2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide

Participants

Role	Name	HCID	Charge
Reactant	Leucine, N-carboxy-, N-benzyl ester, L-	HCID 74840	—
Reactant	N-((Phenylmethoxy)carbonyl)-L-leucyl-L-leucine	HCID 7299379	—
Reactant	Ethyl 2-(aminomethyl)-1,3-thiazole-4-carboxylate	HCID 10442432	—
Reactant	Amino-1-(4carboethoxythiazol-2-yl)-3-methylbutane	HCID 76155321	—
Product	(2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide	HCID 18396119	—

Reaction Steps

Following the of Example 13, except substituting 1-tert-butoxycarbonyl)amino-1-(4-carboethoxythiazol-2yl)methane for (1S)-1-tert-butoxycarbonyl)amino-1-(4carboethoxythiazol-2-yl)-3-methylbutane, and N-Cbz-L-leucine for N-Cbz-L-leucinyl-L-leucine, the title compound was prepared 0.120 g, 32%). MS (MH+): 434.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06331542B1
Source dataset	uspto-grants-2001_12
ORD ID	ord-5a446a71ab514e00ae81ab08667cb52a
Source note	uspto-grants-2001_12