Dimethylformamide → HCID 18331382, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the compound (350 mg) obtained in Example 520b, cesium carbonate (404 mg), dimethylformamide (15 ml) and ethyl iodide (0.4 ml) was stirred at 60° C. for 2 h. To the reaction mixture, ethyl acetate and water were added. The organic layer was washed with a saturated aqueous sodium chloride solution, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent, ethyl acetate:n-hexane=2:8) to give the titled compound quantitatively.

Provenance & Evidence