HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzenesulfonyl)thiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-4-benzenesulfonylthiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzenesulfonyl)thiophene-2-sulfonyl chloride | HCID 625574 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-Bromo-3-methyl-5-isoxazolyl)-4-benzenesulfonylthiophene-2-sulfonamide | HCID 15342062 | 26% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-4-(benzenesulfonyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 4-benzenesulfonylthiophene-2-sulphonyl chloride in 26% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 181-184° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-d2c9d088ee194b9e893528782b96bdad |
| Source note | uspto-grants-2001_12 |