HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-(3,4-dimethyl-5-isoxazolyl)furan-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Amino-3,4-dimethylisoxazole | HCID 88317 | — |
| Reactant | Furan-2-sulfonyl Chloride | HCID 2795072 | — |
| Product | N-(3,4-dimethyl-5-isoxazolyl)furan-2-sulfonamide | HCID 17770370 | — |
Reaction Steps
N-(3,4-dimethyl-5-isoxazolyl)furan-2-sulfonamide was prepared as described in Example 34B from 3,4-dimethyl-5-amino isoxazole (0.122 g, 1.0 mmol), furan-2-sulfonyl chloride (0.50 g, 3.0 mmol) and NaOH (64 mg). Flash chromatography (50% ethyl acetate/hexanes) yielded 70 mg of a yellow solid. Recrystallization from CHCl3/hexanes produced an off-white solid (46 mg, 29% yield), m.p 107-110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-4cd68ef9e7f840e08afdb1ee00838a69 |
| Source note | uspto-grants-2001_12 |