1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(4-chloro-3-methyl-benzoyl)-1H-quinolin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 0.98 mL 0.5M 4-chloro-3-methylphenylmagnesium bromide. Yield: 54 mg of a white solid. LC-MSD, m/z for C23H16BrClN2O2 [M+H]+=467.0, 469.0; HPLC retention time: 2.6 min.

Provenance & Evidence