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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2270621Generated: October 28, 2026

Dimethylformamide → 2-[3,4-(Methylenedioxy)benzyl]-benzo[b]thiophene-3-sulfonylchloride

https://huagongshe.com/reaction/2270621

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantSulfuryl chlorideHCID 24648—
Reactant2-[3,4-(Methylenedioxy)benzyl]benzo[b]thiopheneHCID 22998407—
Product2-[3,4-(Methylenedioxy)benzyl]-benzo[b]thiophene-3-sulfonylchlorideHCID 22998385—

Reaction Steps

2-[3,4-(methylenedioxy)benzyl]benzo[b]thiophene-3-sulfonyl chloride was prepared by the method of Example 40B using DMF (9.1 mmoles, 0.70 ml), sulfuryl chloride (7.7 mmoles, 0.62 ml) and 2-[3,4-(methylenedioxy)benzyl]benzo[b]thiophene (4.6 mmoles, 1.2 g). Flash chromatography (5% ethyl acetate/hexanes) provided 0.71 g (42%) of a light yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06331637B1
Source datasetuspto-grants-2001_12
ORD IDord-3a05de80c1a2424a991361b9b00b8d87
Source noteuspto-grants-2001_12