HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfur Dioxide → 1-Methylindole-2-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfur Dioxide | HCID 1119 | — |
| Reactant | 1-Methylindole | HCID 11781 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Methylindole-2-sulfonyl chloride | HCID 22998502 | — |
Reaction Steps
1-Methylindole-2-sulfonyl chloride was prepared by the method of Example 34 with 1-methylindole (7.8 mmols, 1.0 ml), t-BuLi (1.7 m, 9.4 mmols, 5.5 ml), sulfur dioxide, NCS (8.6 mmols, 1.2 g) and THF (15 ml). Flash chromatography (2% ethyl acetate/hexanes) provided 0.66 g (3%) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-20d405444bd34814be6facdf98b415b7 |
| Source note | uspto-grants-2001_12 |