HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → N-(4-bromo-3-methyl-5-isoxazolyl)-1-methylindole-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Reactant | 1-Methylindole-2-sulfonyl chloride | HCID 22998502 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-bromo-3-methyl-5-isoxazolyl)-1-methylindole-2-sulfonamide | HCID 23445329 | — |
Reaction Steps
N-(4-bromo-3-methyl-5-isoxazolyl)-1-methylindole-2-sulfonamide was prepared by the method of Example 41 with 4-bromo-3-methyl-5-aminoisoxazole (1.0 mmols, 0.18 g), NaH (2.5 mmols, 60 mg), 1-methylindole-2-sulfonyl chloride (1.2 mmols, 0.26 9) and THF (7 ml). Recrystallization from chloroform and hexane provided 0.28 g (77%) of a brown solid, m.p. 132-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-faa3b2ea82db48118fd87a6d17e55c4a |
| Source note | uspto-grants-2001_12 |