4-Bromo-3-methylisoxazol-5-amine → HCID 22998447, compound

HRID 2270628Notes

Reaction equation

HRID 2270628 reaction equation
[O:1]([C:8]1[CH:12]=[CH:11][S:10][C:9]=1[S:13](Cl)(=[O:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[O:22][N:21]=[C:20]([CH3:23])[C:19]=1[Br:24]>>[Br:24][C:19]1[C:20]([CH3:23])=[N:21][O:22][C:18]=1[NH:17][S:13]([C:9]1[S:10][CH:11]=[CH:12][C:8]=1[O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 229984353-Phenoxy-2-thiophenesulfonyl chloride

Product 1

HCID 22998447HCID 22998447, compound

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-3-phenoxythiophene-2-sulfonamide was prepared from 3-phenoxythiophene-2-sulfonyl chloride and 5-amino-4-bromo-3-methylisoxazole using the method described in Example 1. The product was recrystallized from acetonitrile/H2O to give a solid m.p. 121-123° C., 61% yield.

Workup

  1. customThe product was recrystallized from acetonitrile/H2O

Sources & evidence

ORD record
ord-b01be5c5e088458186a62a3a98b79495
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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