2-Chloro-5-iodopyridine → HCID 57754507, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60 from 275 mg (0.68 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 3 mL THF and 360 mg (1.51 mmol) of 2-chloro-5-iodo-pyridine in 2 mL THF with 0.79 mL 2M isopropylmagnesium chloride. Yield: 187 mg of a white powder. LC-MSD, m/z for C21H13BrClN3O2 [M+H]+=454.0, 456.0; HPLC retention time: 2.2 min.

Provenance & Evidence