4-Bromo-3-methylisoxazol-5-amine → HCID 23445302, compound

HRID 2270636Notes

Reaction equation

HRID 2270636 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH2:9]([C:16]1[S:20][C:19]([S:21](Cl)(=[O:23])=[O:22])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:21]([C:19]1[S:20][C:16]([CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:17][CH:18]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 134257165-Benzylthiophene-2-sulfonyl chloride

Product 1

HCID 23445302HCID 23445302, compoundYield 22%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-5-benzylthiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-benzyl-2-thiophenesulfonyl chloride in 22% yield. The product was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid, m.p. 49-50° C.

Workup

  1. customThe product was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid, m.p. 49-50° C.

Sources & evidence

ORD record
ord-1fe3793db70947ecaba1d20b39ff88eb
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

Loading…