4-Bromo-3-methylisoxazol-5-amine → HCID 23445490, compound

HRID 2270646Notes

Reaction equation

HRID 2270646 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:17]2[S:21][C:20]([S:22](Cl)(=[O:24])=[O:23])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:22]([C:20]1[S:21][C:17]([C:13]2[CH:14]=[CH:15][CH:16]=[C:11]([O:10][CH3:9])[CH:12]=2)=[CH:18][CH:19]=1)(=[O:23])=[O:24]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998425HCID 22998425, compound

Product 1

HCID 23445490HCID 23445490, compoundYield 48%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-5-(3-methoxyphenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-(3-methoxyphenyl)thiophene-2-sulfonyl chloride in 48% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) give a solid.

Workup

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customgive a solid

Sources & evidence

ORD record
ord-c0b7cadad24f477aa12c51547f448079
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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