4-Bromo-3-methylisoxazol-5-amine → HCID 23445259, compound

HRID 2270650Notes

Reaction equation

HRID 2270650 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[S:9]1[CH:13]=[CH:12][C:11]([C:14]2[S:18][C:17]([S:19](Cl)(=[O:21])=[O:20])=[CH:16][CH:15]=2)=[CH:10]1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:19]([C:17]1[S:18][C:14]([C:11]2[CH:12]=[CH:13][S:9][CH:10]=2)=[CH:15][CH:16]=1)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998431HCID 22998431, compound

Product 1

HCID 23445259HCID 23445259, compoundYield 40%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-5-(3-thienyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-(3-thienyl)thiophene-2-sulfonyl chloride in 40% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) give a solid.

Workup

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customgive a solid

Sources & evidence

ORD record
ord-6a31696fb1dd4706a1537da4811d2cef
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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