HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(B)Thiophene → a-(2-Benzo[b]thienyl)-3,4-dimethoxybenzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Reactant | Veratraldehyde | HCID 8419 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | a-(2-Benzo[b]thienyl)-3,4-dimethoxybenzyl alcohol | HCID 49962621 | — |
Reaction Steps
a-(2-benzo[b]thienyl)-3,4-dimethoxybenzyl alcohol was prepared in the same manner as described in Example 40A. Reaction of benzo[b]-thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 m, 97 mmoles, 5.7 ml) and 3,4-dimethoxybenzaldehyde (8.9 mmoles, 1.5 g) in THF (20 ml) yielded, after flash chromatography using 30% ethyl acetate/hexanes, 2.25 g (≈100%) of a white gummy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3a8b38394fae45bca45177f614a37692 |
| Source note | uspto-grants-2001_12 |